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The Cochrane Collaboration is an international organisation that aims to help people make wellinformed decisions about healthcare by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of healthcare interventions. It is a not-for-profit organisation, established as a company, limited by guarantee and registered as a charity in the UK. The Cochrane Collaboration's work is based on ten key principles: Collaboration.
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1. Werner, M., Sutherland, E., and Abramson, F., Concepts for the rational selection of assays to be used in monitoring therapeutic drugs. Clin. Chem. 21, 1368-1371 1975 ; . 2. Abramson, F., and Werner, M., Therapeutic drug monitoring. Guidelines Anal. Toxicol. Prog. 1, 61-77 1977 ; . 3. Breitner, J., Helger, R., and Lang, H., Evaluation of column extraction: A new procedure for the analysis of drugs in body fluids. Forensic Sci. 7, 131-140 1976 ; . 4. Abramson, F., Gas-chromatographic identification drugs in of gastric aspirate samples: rapidscreening rocedurefor emergency A p toxicology. Clin. Chem. 22, 1906-1909 1976 ; . 5. Chang, T., and Glazko, A. J., Quantitative assay of 5, 5-diphenylhydantoin and 5- p-hydroxyphenyl ; -5-phenylhydantoin by gasliquid chromatography. J. Lab. Clin. Med. 75, 145-155 1970 ; . 6. Davis, H. L., Falk, K. J., and Bailey, . G., Improved method for D.
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Pictured left to right ; : Lois and Eric S. Santini, owner of Santini Homes Inc., received the Outstanding Citizen Award from Rockville Rotary Club's new President Steve Leibowitz at the club's recent Installation Banquet at Ellington Ridge Country Club. The award honors non-Rotarians whose contributions to the community exemplify the Rotary International goal of service to those in need. The Santinis were recognized because they have given financial help and business services to a wide variety of community organizations. example, similar outreaches are now operating in Hartford and on the island of Nantucket in Massachusetts. Co-founder Chris Luginbuhl, himself a man in recovery, hopes that BPS will become a model not only across New England, but across the United States. "From our biggest cities to our smallest towns, every community in America has major substance abuse issues, " he says. "We can either ignore the problem and allow it to grow by default, pay higher taxes and expect our governments to solve the problem, or we can roll up our sleeves, open our checkbooks, and become part of the solution ourselves." BPS is a "virtual" outreach with no paid staff and no overhead. All donations go toward providing care for those in need. For details, or to make a donation, please call Become Part of the Solution at 860-871-6579 or write: BPS c o Union Congregational Church, 3 Elm Street, Rockville, CT 06066 and hemocyte.
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[3H]acetylcholine release from slices of rat hippocampus, striatum and cortex. Brain Res 123: 31 l-322. Hohmann CF, Brooks AR, Coyle JT 1988 ; Neonatal lesions of the basal forebrain cholinergic neurons result in abnormal cortical development. Dev Brain Res 42: 253-264. Horn JP, Dodd J 198 1 ; Monosynaptic muscarinic activation of K + conductance underlies the slow inhibitory postsynaptic potential in sympathetic ganglia. Nature 292: 625-627. Jan- YN, Jan LY 1983 ; A LHRH-like peptidergic neurotransmitter capable of "action at a distance" in autonomic ganglia. Trends Neurosci 6: 320-325. Lankford KL, DeMello FG, Klein WL 1988 ; D, -type dopamine receptors inhibit growth cone motility in cultured retina neurons: evidence that neurotransmitters act as morphogenic growth regulators in the developing central nervous system. Proc Nat1 Acad Sci USA 85: 2839-2843. Lauder JM 1993 ; Neurotransmitters as growth regulatory signals: role of receptors and second messengers. Trends Neurosci 16: 233-240. Layer PG 199 1 ; Cholinesterases during development of the avian nervous system. Cell Mol Neurobiol 11: 7-33. Layer PG, Kaulich S 199 1 ; Cranial nerve growth in birds is preceded by cholinesterase expression during neural crest cell migration and the formation of an HNK-1 scaffold. Cell Tissue Res 265: 393407. Layer PG, Alber R, Rathjen FG 1988 ; Sequential activation of butyrylcholinesterase in rostra1 half somites and acetylcholinesterase in motoneurones and myotomes preceding growth of motor axons. Development 102: 387-396. Layer PG, Weikert T, Willbold E 1992 ; Chicken retinospheroids as developmental and pharmacological in vitro models: acetylcholinesterase is regulated by its own and by butyrylcholinesterase activity. Cell Tissue Res 268: 409-4 18. Layer PG, Weikert T, Alber R 1993 ; Cholinesterases regulate neurite growth of chick nerve cells in vitro by means of a non-enzymatic mechanism. Cell Tissue Res 273: 219-226. Lipton SA, Kater SB 1989 ; Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. Trends Neurosci 12: 265-270. Lipton SA, Frosch MP, Phillips MD, Tauck DL, Aizenman E 1988 ; Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture. Science 239: 1293-l 296. Lockridge 0 1982 ; Substance P hydrolysis by human serum cholinesterase. J Neurochem 39: 106-l 10. Mattson MP 1988 ; Neurotransmitters in the regulation of neuronal cvtoarchitecture. Brain Res Rev 13: 179-2 12. McCobb DP, Cohan CS, Connor JA, Kater SB 1988 ; Interactive effects of serotonin and acetylcholine on neurite elongation. Neuron 1: 377-385. Mesulam MM, Geula C 1988 ; Acetylcholinesterase-rich pyramidal neurons in the human neocortex and hippocampus: absence at birth, development during the life span, and dissolution in Alzheimer's disease. Ann Neurol 24~765-773. Michaelson S, Small DH 1993 ; A protease is recovered with a dimeric form of acetylcholinesterase in fetal bovine serum. Brain Res 611: 75-80. Olson PF, Fessler LI, Nelson RE, Steme RE, Campbell AG, Fessler JH 1990 ; Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases. EMBO J 9: 1219-1227. Ralston JS, Rush RS, Doctor BP, Wolfe AD 1985 ; Acetylcholinesterase from fetal bovine serum. Purification and characterization of soluble G4 enzyme. J Biol Chem 260: 43 1243 Ramirez G, Barat A, Femandez HL 1990 ; Interaction of asymmetric and globular acetylcholinesterase species with glycosaminoglycans. J Neurochem 54: 176 1-1768. Robertson RT 1987 ; A morphogenic role for transiently expressed acetylcholinesterase in thalamocortical development? Neurosci Lett 75~259-264. Robertson RT, Yu J 1993 ; Acetylcholinesterase and neural development: new tricks for an old don? News Phvsiol Sci 8: 266-272. Robertson RT, Hijhmann CF, Bruce JL, Coy& JT 1988 ; Neonatal enucleations reduce specific activity of acetylcholinesterase but not choline acetyltransferase in developing rat visual cortex. Dev Brain Res 39: 298-302. Rotundo RL, Carbonetto ST 1987 ; Neurons segregate clusters of membrane-bound acetylcholinesterase along their neurites. Proc Nat1 Acad Sci USA 84: 2063-2067.
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